Mutations in PKC Consensus Phosphorylation Sites Affect ASIC1 Channel Activity
نویسندگان
چکیده
منابع مشابه
Two PKC consensus sites on human acid-sensing ion channel 1b differentially regulate its function.
Human acid-sensing ion channel 1b (hASIC1b) is a H(+)-gated amiloride-sensitive cation channel. We have previously shown that glioma cells exhibit an amiloride-sensitive cation conductance. Amiloride and the ASIC1 blocker psalmotoxin-1 decrease the migration and proliferation of glioma cells. PKC also abolishes the amiloride-sensitive conductance of glioma cells and inhibits hASIC1b open probab...
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متن کاملDetermining whether positively-charged channel-forming molecules of polyene antibiotic with aromatic groups affect muscle activity?
This article evaluates the effect of membrane active channel-forming polyene antibiotic (PA) of levorin and its alkyl derivatives on the muscle performance. The membrane channels of muscle cells are capable to transport ions of potassium, sodium, and calcium. In the period of an intensive muscle exercise, the necessity for organic substrates increases and these channels start to work with the g...
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ژورنال
عنوان ژورنال: The FASEB Journal
سال: 2006
ISSN: 0892-6638,1530-6860
DOI: 10.1096/fasebj.20.4.a325-d